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Table 2 Hazard ratios for calibrated energy intake and daily step count status, and all-cause mortality calculated using the multivariable Cox proportional hazards model

From: Association between doubly labelled water-calibrated energy intake and objectively measured physical activity with mortality risk in older adults

 

n

Event

PY

Event/1000 PY

Model 1a

Model 2b

Rate

95%CI

HR

95%CI

HR

95%CI

EI×SC

 LEI/LSC

1352

78

4500

17.3

(13.9 to 21.6)

1.00

(Ref)

1.00

(Ref)

 HEI/LSC

1586

23

5360

4.3

(2.9 to 6.5)

0.72

(0.44 to 1.19)

0.71

(0.41 to 1.23)

 LEI/HSC

471

9

1605

5.6

(2.9 to 10.8)

0.54

(0.27 to 1.08)

0.59

(0.29 to 1.19)

 HEI/HSC

750

1

2582

0.4

(0.1 to 2.7)

0.10

(0.01 to 0.73)

0.10

(0.01 to 0.76)

Interaction

 Additivec

     

-0.16

(-0.90 to 0.58)

-0.20

(-0.89 to 0.49)

 p-value

    

0.701

0.753

 Multiplicatived

   

0.28

(0.03 to 2.32)

0.25

(0.03 to 2.12)

0.25

(0.03 to 2.05)

 p-value

   

0.238

0.205

0.194

EI

 Low

1823

87

6104

14.3

(11.6 to 17.6)

1.00

(Ref)

1.00

(Ref)

 High

2336

24

7942

3.0

(2.0 to 4.5)

0.66

(0.40 to 1.08)

0.64

(0.37 to 1.08)

SC

 Low

2938

101

9859

10.2

(8.4 to 12.5)

1.00

(Ref)

1.00

(Ref)

 High

1221

10

4187

2.4

(1.3 to 4.4)

0.42

(0.22 to 0.82)

0.45

(0.23 to 0.88)

  1. CI, confidence interval; EI, energy intake; HEI, high energy intake; HR, hazard ratio; HSC, high step counts; LEI, low energy intake; LSC, low step counts; PY, person-years; Ref, reference; RERI, Relative Excess Risk due to Interaction; SC, step counts
  2. aModel 1: Adjusted for age, sex, population density, and season of wear
  3. bModel 2: Adjusted for Model 1 and body mass index, smoking status, alcohol consumption status, family structure, educational attainment, economic status, denture use, medication use, number of chronic diseases, and frailty status
  4. cThe additive interaction was calculated as the RERI using the following equation: RERI = (HR [HEI/HSC] − 1) + (HR [HEI/LSC] + HR [LEI/HSC] − 2). The values are shown as RERI (%). It is significant (p < 0.05) if the 95% CI of the RERI is not above 0
  5. dIt is significant (p < 0.05) if the 95% CI of the multiplicative interaction is not above 1.00