Cross-sectional associations between 24-hour time-use composition, grey matter volume and cognitive function in healthy older adults

Mellow, Maddison L; Dumuid, Dorothea; Olds, Timothy; Stanford, Ty; Dorrian, Jillian; Wade, Alexandra T; Fripp, Jurgen; Xia, Ying; Goldsworthy, Mitchell R; Karayanidis, Frini; Breakspear, Michael J; Smith, Ashleigh E

doi:10.1186/s12966-023-01557-4

International Journal of Behavioral Nutrition and Physical Activity

Table 4 Linear regression outputs

From: Cross-sectional associations between 24-hour time-use composition, grey matter volume and cognitive function in healthy older adults

		Cognitive outcome
		Long-term memory			Executive function			Processing speed
ROI outcome: total grey matter volume
		F	p	*adj.p*	F	p	*adj.p*	F	p	*adj.p*
Model	Age	0.10	0.747	0.747	17.95	0.000	0.000	5.29	0.022	0.066
	Sex	2.96	0.086	0.172	15.33	0.000	0.000	0.23	0.631	0.814
	Education	1.35	0.248	0.372	4.92	0.027	0.033	0.00	0.944	0.944
	Time-use composition	2.88	0.036	0.107	0.17	0.917	0.917	4.09	0.007	0.043
	ROI volume	0.79	0.374	0.449	8.66	0.003	0.007	0.92	0.337	0.675
	Time-use composition * ROI volume	3.79	0.011	0.064	3.37	0.018	0.028	0.51	0.678	0.813
ROI outcome: temporal lobe volume
		F	p	*adj.p*	F	p	*adj.p*	F	p	*adj.p*
Model	Age	0.21	0.647	0.693	25.19	0.000	0.000	5.40	0.021	0.062
	Sex	2.99	0.085	0.255	13.90	0.000	0.000	0.24	0.623	0.935
	Education	1.43	0.233	0.467	4.73	0.030	0.061	0.00	0.944	0.944
	Time-use composition	2.77	0.041	0.248	0.20	0.898	0.898	4.03	0.007	0.046
	ROI volume	0.39	0.535	0.693	2.47	0.117	0.176	0.27	0.600	0.935
	Time-use composition * ROI volume	0.48	0.693	0.693	0.84	0.472	0.566	0.24	0.869	0.944
ROI outcome: frontal lobe volume
		F	p	*adj.p*	F	p	*adj.p*	F	p	*adj.p*
Model	Age	0.01	0.933	0.933	22.69	0.000	0.000	6.09	0.014	0.042
	Sex	3.33	0.069	0.138	17.71	0.000	0.000	0.34	0.557	0.836
	Education	1.85	0.174	0.209	4.07	0.044	0.053	0.01	0.922	0.922
	Time-use composition	2.70	0.045	0.136	0.29	0.832	0.832	3.90	0.009	0.042
	ROI volume	1.99	0.159	0.209	7.64	0.006	0.012	1.72	0.190	0.380
	Time-use composition * ROI volume	4.74	0.003	0.018	3.70	0.012	0.018	0.23	0.878	0.921
ROI outcome: hippocampus volume
		F	p	*adj.p*	F	p	*adj.p*	F	p	*adj.p*
Model	Age	0.03	0.871	0.871	23.91	0.000	0.000	4.89	0.027	0.083
	Sex	4.21	0.041	0.094	11.35	0.000	0.003	0.14	0.704	0.864
	Education	1.44	0.231	0.277	4.61	0.032	0.065	0.03	0.864	0.864
	Time-use composition	2.67	0.047	0.094	0.21	0.886	0.886	3.96	0.008	0.051
	ROI volume	4.90	0.028	0.094	1.17	0.279	0.336	0.12	0.729	0.864
	Time-use composition * ROI volume	2.32	0.076	0.113	1.97	0.117	0.177	0.37	0.776	0.864

Note: Linear regression outputs investigating main effects of time-use composition, ROI volume and covariates, and interaction effects on cognitive outcomes. adj.p = p-value adjusted for false discovery rate. Bold denotes p-values that remained significant after false discovery rate adjustment (p < 0.05). Sample sizes for each cognitive outcome varied due to missing data: long-term memory, n = 360; executive function, n = 363; processing speed, n = 368

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ISSN: 1479-5868

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