Table 3 Patient-reported outcomes at T0 and T1 with corresponding changes in both groups

Quality of Life (EORTC-QLQ- C30)

 Global quality of life

 Physical functioning

 Role functioning

 Emotional functioning

 Cognitive functioning

 Social functioning

 Sum score

69.6 ± 17.6

83.1 ± 12.1

68.4 ± 25.6

73.4 ± 21.9

68.9 ± 25.2

75.3 ± 27.8

73.1 ± 15.6

71.7 ± 17.9

84.3 ± 14.8

72.8 ± 26.1

80.6 ± 17.5

75.4 ± 19.9

79.6 ± 26.1

77.4 ± 14.4

2.1 (-4.1;8.3)

1.2 (-3.2;5.5)

4.4 (-5.4;14.2)

7.2 (-0.8;15.2)

6.5 (-0.7;13.7)

4.3 (-5.4;14.1)

4.3 (-0.5;9.1)

69.3 ± 15.1

84.7 ± 12.9

72.7 ± 21.1

74.1 ± 23.1

69.5 ± 25.0

77.5 ± 24.7

74.6 ± 15.3

70.8 ± 19.7

84.1 ± 15.9

71.4 ± 22.4

70.6 ± 25.1

71.3 ± 23.7

75.5 ± 25.3

74.0 ± 16.5

1.6 (-2.6;5.8)

-0.6 (-3.9;2.7)

-1.3 (-8.4;5.9)

-3.4 (-9.8;3.0)

1.8 (-3.8;7.3)

-2.0 (-10.6;6.5)

-0.7 (-4.4;3.1)

Fatigue (MFI-20)

 General fatigue

 Physical fatigue

 Reduced motivation

 Reduced activity

 Mental fatigue

 Sum score

13 ± 4

11 ± 4

10 ± 4

11 ± 4

12 ± 4

57 ± 15

12 ± 4

11 ± 5

9 ± 4

10 ± 4

11 ± 4

53 ± 16

-1 (-2;1)

-1 (-2;1)

-1 (-3;0)

-1 (-2;0)

-1 (-3;0)

-5 (-10;0)

12 ± 4

10 ± 4

9 ± 4

11 ± 4

12 ± 4

54 ± 18

12 ± 5

11 ± 5

10 ± 5

11 ± 5

11 ± 5

55 ± 20

0 (-1;1)

1 (-1;2)

0 (-1;1)

0 (-1;1)

0 (-1;1)

0 (-4;5)

Anxiety and depression (HADS)

 Anxiety

 Depression

 Sum score

7 ± 4

5 ± 4

11 ± 6

6 ± 4

4 ± 3

10 ± 6

-1 (-2;1)

-1 (-2;1)

-1 (-3;1)

7 ± 4

5 ± 4

12 ± 8

6 ± 4

5 ± 4

11 ± 8

0 (-1;0)

0 (-1;1)

-1 (-2;1)

Return to work^A

 No, n(%)

 Yes, n(%)

 Hours returned (%)*

20 (51%)

19 (49%)

22 ± 32

8 (24%)

25 (76%)

51 ± 43

-

-

29 (16;42*)

17 (45%)

21 (55%)

23 ± 29

10 (29%)

24 (71%)

58 ± 49

-

-

35 (18;51*)