|
Analysis
|
Sample size per group
|
ΔC (95% CI)
|
ΔE (95% CI)
| |
Distribution in CE plane (%)
|
|---|
| |
Control
|
Internet
| |
Weight loss (kg)
|
ICER
|
NE
b
|
SE
c
|
SW
d
|
NW
e
|
|---|
|
Main
|
448
|
450
|
14 (−790; 867)
|
0.9 (−0.1; 1.9)
|
16
|
50
|
48
|
1
|
1
|
|
Complete cases
|
134
|
129
|
-82 (-838 to 633)
|
1.3* (0.3; 2.4)
|
−62
|
41
|
58
|
0
|
0
|
|
Company perspective
|
448
|
450
|
−149 (−858; 618)
|
0.9 (−0.1; 1.9)
|
−171
|
33
|
65
|
2
|
1
|
| | | | |
QALY
|
ICUR
| | | | |
|
Main
|
448
|
450
|
14 (−774; 887)
|
0.01 (−0.01; 0.04)
|
1337
|
35
|
47
|
5
|
14
|
|
Complete cases
|
120
|
125
|
−307 (−1179; 315)
|
0.02 (−0.02; 0.06)
|
−27,908
|
17
|
71
|
8
|
5
|
|
Company perspective
|
448
|
450
|
−149 (−858; 618)
|
0.01 (−0.01; 0.04)
|
−14,181
|
23
|
58
|
8
|
11
|
|
UK tariff
|
448
|
450
|
14 (−774; 887)
|
0.02 (−0.02;0.06)
|
702
|
41
|
47
|
4
|
9
|
- a In the analysis ΔC= mean difference in total costs, ΔE= mean difference in outcome, ICER (ICUR) =incremental cost-effectiveness (utility) ratio calculated as ΔC/ΔE. In the main analysis missing data were multiply imputed. The complete cases analysis was restricted to participants with complete cost and effect data. b Northeast quadrant of the CE-plane: the intervention is more effective and more costly than self-help brochures. Southeast quadrant of the CE-plane: the intervention is more effective and less costly than self-help brochures. d Southwest quadrant of the CE-plane: the intervention is less effective and less costly than self-help brochures. e Northwest quadrant of the CE-plane: the intervention is less effective and more costly than self-help brochures. *p=0.01.
