|  | Total effect | Direct effect | Indirect effect |  | |||
---|---|---|---|---|---|---|---|---|
Exposure | Mediator | OR [95% CI] | P-value | OR [95% CI] | P-value | OR [95% CI] | P-value | % Mediated |
Arthritis | Anxiety | 1.22 [1.04,1.45] | 0.017 | 1.21 [1.03,1.43] | 0.023 | 1.01 [1.00,1.02] | 0.064 | NA |
Cognition | 1.23 [1.04,1.46] | 0.014 | 1.15 [0.97,1.37] | 0.108 | 1.07 [1.04,1.10] | <0.001 | 32.8 | |
Depression | 1.22 [1.04,1.45] | 0.018 | 1.21 [1.02,1.43] | 0.030 | 1.02 [1.01,1.03] | 0.003 | 7.7 | |
Sleep/energy | 1.23 [1.04,1.45] | 0.017 | 1.11 [0.94,1.31] | 0.225 | 1.11 [1.07,1.14] | <0.001 | 49.1 | |
Asthma | Anxiety | 1.38 [1.06,1.81] | 0.017 | 1.30 [0.99,1.70] | 0.059 | 1.06 [1.03,1.10] | <0.001 | 19.3 |
Cognition | 1.40 [1.07,1.83] | 0.014 | 1.27 [0.97,1.66] | 0.082 | 1.10 [1.06,1.14] | <0.001 | 28.7 | |
Depression | 1.39 [1.06,1.81] | 0.016 | 1.33 [1.02,1.74] | 0.036 | 1.04 [1.02,1.07] | 0.003 | 13.2 | |
Sleep/energy | 1.38 [1.07,1.79] | 0.014 | 1.21 [0.93,1.56] | 0.155 | 1.15 [1.10,1.20] | <0.001 | 42.3 | |
Chronic back pain | Anxiety | 1.71 [1.36,2.14] | <0.001 | 1.61 [1.28,2.03] | <0.001 | 1.06 [1.03,1.09] | <0.001 | 10.6 |
Cognition | 1.74 [1.38,2.18] | <0.001 | 1.48 [1.18,1.86] | 0.001 | 1.17 [1.12,1.23] | <0.001 | 28.7 | |
Depression | 1.71 [1.37,2.14] | <0.001 | 1.65 [1.32,2.07] | <0.001 | 1.03 [1.01,1.06] | 0.003 | 6.2 | |
Sleep/energy | 1.70 [1.36,2.13] | <0.001 | 1.50 [1.19,1.89] | 0.001 | 1.13 [1.08,1.18] | <0.001 | 23.6 | |
Chronic lung disease | Anxiety | 1.48 [1.18,1.85] | 0.001 | 1.39 [1.11,1.74] | 0.005 | 1.07 [1.04,1.10] | <0.001 | 16.4 |
Cognition | 1.48 [1.19,1.84] | <0.001 | 1.33 [1.07,1.66] | 0.011 | 1.11 [1.08,1.15] | <0.001 | 27.6 | |
Depression | 1.48 [1.19,1.85] | 0.001 | 1.43 [1.15,1.79] | 0.001 | 1.03 [1.01,1.05] | 0.002 | 8.2 | |
Sleep/energy | 1.49 [1.19,1.85] | <0.001 | 1.32 [1.06,1.65] | 0.013 | 1.13 [1.08,1.17] | <0.001 | 29.9 | |
Hearing problems | Anxiety | 1.58 [1.24,2.03] | <0.001 | 1.54 [1.21,1.97] | 0.001 | 1.03 [1.00,1.05] | 0.036 | 6.0 |
Cognition | 1.60 [1.24,2.05] | <0.001 | 1.36 [1.06,1.75] | 0.015 | 1.17 [1.12,1.22] | <0.001 | 33.4 | |
Depression | 1.57 [1.22,2.02] | 0.001 | 1.57 [1.21,2.02] | 0.001 | 1.00 [0.99,1.02] | 0.842 | NA | |
Sleep/energy | 1.59 [1.24,2.05] | <0.001 | 1.50 [1.17,1.94] | 0.002 | 1.06 [1.03,1.09] | <0.001 | 12.2 | |
Stroke | Anxiety | 2.02 [1.52,2.69] | <0.001 | 1.97 [1.48,2.61] | <0.001 | 1.03 [1.00,1.06] | 0.054 | NA |
Cognition | 2.03 [1.56,2.66] | <0.001 | 1.75 [1.33,2.29] | <0.001 | 1.16 [1.11,1.23] | <0.001 | 21.5 | |
Depression | 2.03 [1.54,2.66] | <0.001 | 2.00 [1.52,2.63] | <0.001 | 1.01 [1.00,1.03] | 0.112 | NA | |
Sleep/energy | 2.03 [1.56,2.64] | <0.001 | 1.90 [1.46,2.48] | <0.001 | 1.07 [1.03,1.11] | <0.001 | 9.3 | |
Visual impairment | Anxiety | 2.64 [1.75,3.99] | <0.001 | 2.10 [1.38,3.21] | 0.001 | 1.26 [1.13,1.39] | <0.001 | 23.5 |
Cognition | 2.66 [1.73,4.10] | <0.001 | 1.97 [1.27,3.06] | 0.002 | 1.35 [1.23,1.48] | <0.001 | 30.7 | |
Depression | 2.60 [1.73,3.91] | <0.001 | 2.43 [1.62,3.65] | <0.001 | 1.07 [1.02,1.12] | 0.009 | 6.9 | |
Sleep/energy | 2.64 [1.75,3.99] | <0.001 | 2.29 [1.51,3.47] | <0.001 | 1.15 [1.08,1.23] | <0.001 | 14.6 | |
Multimorbiditya | Anxiety | 1.41 [1.20,1.67] | <0.001 | 1.36 [1.15,1.60] | <0.001 | 1.04 [1.02,1.06] | <0.001 | 11.5 |
Cognition | 1.40 [1.19,1.65] | <0.001 | 1.24 [1.05,1.47] | 0.012 | 1.12 [1.09,1.16] | <0.001 | 35.0 | |
Depression | 1.41 [1.19,1.66] | <0.001 | 1.37 [1.16,1.62] | <0.001 | 1.03 [1.01,1.04] | 0.001 | 7.5 | |
Sleep/energy | 1.40 [1.19,1.66] | <0.001 | 1.23 [1.05,1.45] | 0.012 | 1.14 [1.09,1.19] | <0.001 | 38.1 |