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Table 4 Disability, mobility, and pain/discomfort as mediators in the association between chronic conditions (multimorbidity) and highly sedentary behavior among adults aged ≥50 years

From: Physical chronic conditions, multimorbidity and sedentary behavior amongst middle-aged and older adults in six low- and middle-income countries

  

Total effect

Direct effect

Indirect effect

 

Exposure

Mediator

OR [95% CI]

P-value

OR [95% CI]

P-value

OR [95% CI]

P-value

% Mediated

Arthritis

Disability

1.23 [1.04,1.46]

0.017

1.04 [0.87,1.24]

0.670

1.18 [1.14,1.23]

<0.001

81.6

Mobility

1.23 [1.04,1.45]

0.015

1.02 [0.86,1.22]

0.780

1.20 [1.15,1.25]

<0.001

88.1

Pain/discomfort

1.23 [1.04,1.46]

0.016

1.03 [0.87,1.22]

0.732

1.19 [1.14,1.25]

<0.001

85.6

Asthma

Disability

1.41 [1.07,1.85]

0.014

1.07 [0.81,1.41]

0.638

1.32 [1.24,1.40]

<0.001

80.6

Mobility

1.41 [1.08,1.84]

0.011

1.12 [0.86,1.45]

0.413

1.27 [1.20,1.33]

<0.001

68.4

Pain/discomfort

1.41 [1.08,1.84]

0.011

1.21 [0.93,1.58]

0.158

1.17 [1.11,1.22]

<0.001

44.5

Chronic back pain

Disability

1.71 [1.35,2.17]

<0.001

1.28 [1.02,1.60]

0.035

1.34 [1.26,1.43]

<0.001

54.7

Mobility

1.75 [1.38,2.22]

<0.001

1.36 [1.08,1.72]

0.009

1.29 [1.22,1.36]

<0.001

44.9

Pain/discomfort

1.73 [1.37,2.17]

<0.001

1.36 [1.09,1.69]

0.007

1.27 [1.19,1.36]

<0.001

43.8

Chronic lung disease

Disability

1.49 [1.19,1.86]

<0.001

1.16 [0.93,1.45]

0.191

1.28 [1.22,1.35]

<0.001

62.5

Mobility

1.50 [1.21,1.87]

<0.001

1.19 [0.96,1.46]

0.110

1.27 [1.21,1.33]

<0.001

58.1

Pain/discomfort

1.49 [1.20,1.85]

<0.001

1.27 [1.02,1.58]

0.032

1.18 [1.12,1.23]

<0.001

40.4

Hearing problems

Disability

1.58 [1.21,2.05]

0.001

1.19 [0.91,1.55]

0.194

1.32 [1.24,1.42]

<0.001

61.4

Mobility

1.60 [1.23,2.07]

<0.001

1.35 [1.04,1.75]

0.024

1.18 [1.13,1.24]

<0.001

35.8

Pain/discomfort

1.59 [1.23,2.05]

<0.001

1.46 [1.13,1.87]

0.003

1.09 [1.05,1.13]

<0.001

18.6

Stroke

Disability

2.01 [1.52,2.67]

<0.001

1.40 [1.04,1.87]

0.026

1.44 [1.32,1.58]

<0.001

52.3

Mobility

2.02 [1.54,2.65]

<0.001

1.48 [1.12,1.98]

0.007

1.36 [1.27,1.46]

<0.001

43.8

Pain/discomfort

2.04 [1.57,2.66]

<0.001

1.83 [1.41,2.39]

<0.001

1.11 [1.07,1.17]

<0.001

15.2

Visual impairment

Disability

2.79 [1.85,4.22]

<0.001

1.35 [0.88,2.05]

0.165

2.08 [1.77,2.43]

<0.001

71.1

Mobility

2.76 [1.80,4.25]

<0.001

1.79 [1.16,2.74]

0.008

1.55 [1.40,1.71]

<0.001

43.0

Pain/discomfort

2.68 [1.77,4.06]

<0.001

2.09 [1.38,3.17]

0.001

1.28 [1.19,1.39]

<0.001

25.4

Multimorbiditya

Disability

1.36 [1.15,1.61]

<0.001

1.03 [0.87,1.23]

0.705

1.32 [1.25,1.39]

<0.001

89.1

Mobility

1.39 [1.18,1.64]

<0.001

1.05 [0.89,1.24]

0.570

1.32 [1.26,1.40]

<0.001

85.1

Pain/discomfort

1.40 [1.18,1.66]

<0.001

1.14 [0.97,1.35]

0.119

1.22 [1.16,1.30]

<0.001

60.2

  1. Abbreviation: OR Odds ratio, CI Confidence interval
  2. Highly sedentary behavior referred to being sedentary for ≥8 h/day
  3. Models are adjusted for sex, age, education, wealth, setting, unemployment, living arrangement, and country. For individual chronic conditions, the models were also adjusted for the presence of other chronic conditions
  4. The mediated percentage was only calculated in the presence of a significant indirect effect (P < 0.05)
  5. aMultimorbidity was defined as ≥2 chronic conditions