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Table 3 Cross-sectional associations between prolonged sedentary time and cardio-metabolic risk, ICAD

From: Substituting prolonged sedentary time and cardiovascular risk in children and youth: a meta-analysis within the International Children’s Accelerometry database (ICAD)

Outcome/N includedModelPST, > 15 min bouts (h/day)P sex
interaction
 AllBoysGirls
Standardized BMI 19,477A0.029 (0.001; 0.058)0.117
B0.00 (−0.02; 0.03) 
Waist circumference (cm) 19,502 (boys: 9440; girls: 10,062)A0.30 (0.04; 0.56)0.50 (0.16; 0.84)0.12 (−0.14; 0.38)0.001
B0.10 (−0.11; 0.31)0.22 (−0.05; 0.48)− 0.01 (− 0.25; 0.24) 
Triacylglycerol (mmol/l) 5330A0.002 (− 0.000; 0.004)0.233
B0.000 (−0.002; 0.002) 
C0.000 (−0.001; 0.002) 
HDL-cholesterol (mmol/l) 7849 (boys: 3918; girls: 4031)A− 0.006 (− 0.011; − 0.000)−0.014 (− 0.022; − 0.007)0.001 (− 0.007; 0.008)0.001
B0.00 (− 0.01; 0.01)−0.008 (− 0.016; − 0.001)0.005 (− 0.002; 0.013) 
C− 0.00 (− 0.01; 0.00)− 0.007 (− 0.015; 0.001)0.003 (− 0.004; 0.011) 
Systolic blood pressure (mmHg) 14,726 (boys: 7177; girls: 7549)A0.17 (0.02; 0.33)0.14 (− 0.04; 0.32)0.20 (− 0.12; 0.52)0.045
B0.05 (− 0.09; 0.18)0.01 (− 0.18; 0.21)0.07 (− 0.23; 0.37) 
C− 0.01 (− 0.13; 0.12)− 0.06 (− 0.24; 0.12)0.07 (− 0.14; 0.29) 
Diastolic blood pressure (mmHg)
14,687 (boys: 7155; girls: 7532)
A0.19 (0.09; 0.29)0.07 (− 0.07; 0.21)0.30 (0.17; 0.44)0.009
B0.09 (− 0.01; 0.20)− 0.02 (− 0.17; 0.14)0.17 (0.03; 0.32) 
C0.05 (−0.05; 0.15)−0.07 (− 0.22; 0.08)0.14 (− 0.01; 0.28) 
Fasting plasma glucose (mmol/l) 4952A0.005 (− 0.004; 0.014)0.624
B−0.00 (− 0.01; 0.01) 
C−0.00 (− 0.01; 0.01) 
Fasting serum insulin (pmol/l) 4912A0.00 (−0.00; 0.01)0.681
B−0.00 (− 0.01; 0.00) 
C−0.00 (− 0.01; 0.00) 
CCMR 4595 (boys: 2276; girls: 2319)A0.014 (0.001; 0.028)0.018 (0.002; 0.034)0.008 (− 0.017; 0.033)0.030
B−0.00 (− 0.01; 0.01)0.000 (− 0.020; 0.021)− 0.003 (− 0.021; 0.014) 
CCMRno adip 4595 (boys: 2276; girls: 2319)A0.02 (− 0.00; 0.03)0.022 (0.007; 0.037)0.007 (− 0023; 0.037)0.036
B− 0.00 (− 0.01; 0.01)0.002 (− 0.018; 0.022)− 0.006 (− 0.028; 0.016) 
C0.00 (− 0.01; 0.01)0.004 (− 0.011; 0.018)− 0.005 (− 0.028; 0.017) 
  1. Results are regression coefficients (95% CI) from meta-analysis, representing the difference in mean value of the outcome for every 1 h increase in PST. Statistically significant (P < 0.05) estimates are indicated in bold. Sex-specific associations are provided when a significant interaction with sex was found
  2. Models A were adjusted for sex (in total group), age and wear time (h/day). Models B were additionally adjusted for time spent in moderate-to-vigorous physical activity. Models C were additionally adjusted for waist circumference
  3. Abbrevations: PST prolonged sedentary time, CCMR clustered cardio-metabolic risk score including waist circumference, CCMRno adip clustered cardio-metabolic risk score excluding waist circumference