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Table 3 Cross-sectional associations between prolonged sedentary time and cardio-metabolic risk, ICAD

From: Substituting prolonged sedentary time and cardiovascular risk in children and youth: a meta-analysis within the International Children’s Accelerometry database (ICAD)

Outcome/N included

Model

PST, > 15 min bouts (h/day)

P sex

interaction

 

All

Boys

Girls

Standardized BMI 19,477

A

0.029 (0.001; 0.058)

–

–

0.117

B

0.00 (−0.02; 0.03)

–

–

 

Waist circumference (cm) 19,502 (boys: 9440; girls: 10,062)

A

0.30 (0.04; 0.56)

0.50 (0.16; 0.84)

0.12 (−0.14; 0.38)

0.001

B

0.10 (−0.11; 0.31)

0.22 (−0.05; 0.48)

− 0.01 (− 0.25; 0.24)

 

Triacylglycerol (mmol/l) 5330

A

0.002 (− 0.000; 0.004)

–

–

0.233

B

0.000 (−0.002; 0.002)

–

–

 

C

0.000 (−0.001; 0.002)

–

–

 

HDL-cholesterol (mmol/l) 7849 (boys: 3918; girls: 4031)

A

− 0.006 (− 0.011; − 0.000)

−0.014 (− 0.022; − 0.007)

0.001 (− 0.007; 0.008)

0.001

B

0.00 (− 0.01; 0.01)

−0.008 (− 0.016; − 0.001)

0.005 (− 0.002; 0.013)

 

C

− 0.00 (− 0.01; 0.00)

− 0.007 (− 0.015; 0.001)

0.003 (− 0.004; 0.011)

 

Systolic blood pressure (mmHg) 14,726 (boys: 7177; girls: 7549)

A

0.17 (0.02; 0.33)

0.14 (− 0.04; 0.32)

0.20 (− 0.12; 0.52)

0.045

B

0.05 (− 0.09; 0.18)

0.01 (− 0.18; 0.21)

0.07 (− 0.23; 0.37)

 

C

− 0.01 (− 0.13; 0.12)

− 0.06 (− 0.24; 0.12)

0.07 (− 0.14; 0.29)

 

Diastolic blood pressure (mmHg)

14,687 (boys: 7155; girls: 7532)

A

0.19 (0.09; 0.29)

0.07 (− 0.07; 0.21)

0.30 (0.17; 0.44)

0.009

B

0.09 (− 0.01; 0.20)

− 0.02 (− 0.17; 0.14)

0.17 (0.03; 0.32)

 

C

0.05 (−0.05; 0.15)

−0.07 (− 0.22; 0.08)

0.14 (− 0.01; 0.28)

 

Fasting plasma glucose (mmol/l) 4952

A

0.005 (− 0.004; 0.014)

–

–

0.624

B

−0.00 (− 0.01; 0.01)

–

–

 

C

−0.00 (− 0.01; 0.01)

–

–

 

Fasting serum insulin (pmol/l) 4912

A

0.00 (−0.00; 0.01)

–

–

0.681

B

−0.00 (− 0.01; 0.00)

–

–

 

C

−0.00 (− 0.01; 0.00)

–

–

 

CCMR 4595 (boys: 2276; girls: 2319)

A

0.014 (0.001; 0.028)

0.018 (0.002; 0.034)

0.008 (− 0.017; 0.033)

0.030

B

−0.00 (− 0.01; 0.01)

0.000 (− 0.020; 0.021)

− 0.003 (− 0.021; 0.014)

 

CCMRno adip 4595 (boys: 2276; girls: 2319)

A

0.02 (− 0.00; 0.03)

0.022 (0.007; 0.037)

0.007 (− 0023; 0.037)

0.036

B

− 0.00 (− 0.01; 0.01)

0.002 (− 0.018; 0.022)

− 0.006 (− 0.028; 0.016)

 

C

0.00 (− 0.01; 0.01)

0.004 (− 0.011; 0.018)

− 0.005 (− 0.028; 0.017)

 
  1. Results are regression coefficients (95% CI) from meta-analysis, representing the difference in mean value of the outcome for every 1 h increase in PST. Statistically significant (P < 0.05) estimates are indicated in bold. Sex-specific associations are provided when a significant interaction with sex was found
  2. Models A were adjusted for sex (in total group), age and wear time (h/day). Models B were additionally adjusted for time spent in moderate-to-vigorous physical activity. Models C were additionally adjusted for waist circumference
  3. Abbrevations: PST prolonged sedentary time, CCMR clustered cardio-metabolic risk score including waist circumference, CCMRno adip clustered cardio-metabolic risk score excluding waist circumference
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International Journal of Behavioral Nutrition and Physical Activity

ISSN: 1479-5868

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