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Table 4 Cross-sectional iso-temporal models examining substitution of prolonged sedentary time with non-prolonged sedentary time, light and moderate-to-vigorous physical activity, ICAD

From: Substituting prolonged sedentary time and cardiovascular risk in children and youth: a meta-analysis within the International Children’s Accelerometry database (ICAD)

Outcome Substitution of PST > 15 min bouts
(h/day)
With non-PST ≤ 15 min bouts (h/day)With LIPA
(h/day)
With MVPA
(h/day)
Standardized BMIAll−0.06 (− 0.09; − 0.03)0.01 (− 0.02; 0.03)−0.44 (− 0.62; − 0.26)
Waist circumference (cm)All−0.18 (− 0.46; 0.09)−0.10 (− 0.32; 0.12)−3.07 (− 4.47; − 1.68)
Boys−0.34 (− 0.70; 0.03)−0.22 (− 0.49; 0.04)−3.46 (− 4.92; − 2.00)
Girls−0.06 (− 0.44; 0.31)0.02 (− 0.24; 0.27)− 2.65 (− 4.10; − 1.19)
HDL-cholesterol (mmol/l)All0.000 (− 0.018; 0.019)0.000 (− 0.006; 0.006)0.054 (0.005; 0.104)
Boys0.003 (− 0.015; 0.020)0.010 (0.001; 0.019)0.048 (− 0.013; 0.108)
Girls− 0.002 (− 0.026; 0.023)−0.007 (− 0.017; 0.004)0.073 (0.034; 0.111)
Systolic blood pressure (mmHg)All−0.03 (− 0.33; 0.27)−0.04 (− 0.22; 0.14)−1.53 (− 2.42; − 0.65)
Boys0.01 (− 0.35; 0.36)−0.03 (− 0.24; 0.17)−1.48 (− 2.54; − 0.43)
Girls−0.15 (− 0.54; 0.24)−0.05 (− 0.42; 0.32)−1.91 (− 3.09; − 0.73)
Diastolic blood pressure (mmHg)All0.33 (0.06; 0.60)−0.16 (− 0.28; − 0.04)−0.81 (− 1.38; − 0.24)
Boys0.31 (0.03; 0.60)− 0.04 (− 0.20; 0.13)−0.55 (− 1.34; 0.24)
Girls0.41 (0.01; 0.82)−0.28 (− 0.48; − 0.07)−1.33 (− 2.14; − 0.51)
CCMRAll0.01 (− 0.01; 0.03)−0.00 (− 0.02; 0.01)−0.18 (− 0.27; − 0.10)
Boys0.02 (− 0.01; 0.05)−0.01 (− 0.03; 0.02)−0.15 (− 0.23; − 0.06)
Girls−0.01 (− 0.04; 0.02)0.01 (− 0.01; 0.04)−0.22 (− 0.33; − 0.11)
CCMRno adipAll0.01 (− 0.01; 0.04)−0.00 (− 0.02; 0.01)−0.20 (− 0.29; − 0.11)
Boys0.03 (− 0.01; 0.07)−0.01 (− 0.03; 0.02)−0.15 (− 0.25; − 0.06)
Girls−0.01 (− 0.04; 0.02)0.01 (− 0.02; 0.04)−0.24 (− 0.36; − 0.12)
  1. Results are regression coefficients (95% CI) from meta-analysis, representing the difference in the outcome variable when increasing that type of activity by 1 h/day while decreasing PST by the same duration and holding other activity components constant. Differences in outcome variables when modelling 30 min/day substitutions instead of 1 h/day substitutions (holding other activity components constant) equate to 50% of the estimates presented above. Statistically significant (P < 0.05) estimates are indicated in bold. Sex-specific associations are provided when a significant interaction with sex was found in Table 3
  2. Models omitted the PST variable under study and incorporated the complementary non-prolonged ST variable of interest, LIPA and MVPA, and are adjusted for wear time (h/day), sex (in total group) and age
  3. Abbrevations: PST prolonged sedentary time, non-PST non-prolonged sedentary time, LIPA light-intensity physical activity, MVPA moderate-to-vigorous physical activity, CCMR clustered cardio-metabolic risk score including waist circumference, CCMRno adip clustered cardio-metabolic risk score excluding waist circumference
  4. N included by outcome: see Table 3