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Table 3 Association of daily step counts at baseline and outcome in selected studiesa

From: Systematic review of the prospective association of daily step counts with risk of mortality, cardiovascular disease, and dysglycemia

Reference

Sample size (events; %)

Age, years

mean ± SD or median (IQR)

Outcome

Follow-up time (years)

Study reported

Standardizedb

Daily step count unit

Tested for non-linearity

Risk reduction

Risk reduction

Dwyer, 2015 [15]

2576 (219; 8.5%)

58.8 ± 13.2

All-cause mortality

10

1000 steps/day

Yes

6%

6%

Yamamoto, 2018c [19]

419 (76; 18.1%)

71.0 ± 0.0

All-cause mortality

10

1000 steps/day

Yes

7%c

7%c

Jefferis, 2019 [17]

1181 (194; 16.4%)

78.4 ± 4.6

All-cause mortality

5

1000 steps/day

Yes

14%

14%

Fox, 2015 [16]

201 (33; 16.4%)

Not reported

All-cause mortality

4–5

1000 steps/day

No

36%

36%

Lee, 2019 [18]

16,741 (504; 3%)

72.0 ± 5.7

All-cause mortality

4

1000 steps/day

Yes

18%

18%

Jefferis, 2019 [22]

1181 (122; 10.3%)

78.4 ± 4.6

Myocardial infarction, stroke, or heart failure morbidity or mortality

5

1000 steps/day

Yes

14%

14%

Yates, 2014 [23]

9018 (531; 5.9%)

63.0 (58.0–69.0)

Composite of time to death from cardiovascular causes, non-fatal myocardial infarction, or non-fatal stroke

5

2000 steps/day

Yes

10%

5%

Cochrane, 2017 [20]

1590 (234; 14.7%)

78.9 ± 5.2

Composite of cardiovascular disease events

2

500 steps/day

No

11%

21%

Kraus, 2018 [26]

9306 (3254;35.0%)

65.0 (59.0–71.0)

Diabetes incidence

5

2000 steps/day

Yes

4%

2%

Ponsonby, 2011 [27]

458 (26; 5.7%)

49.7 ± 1.5

Incident dysglycemia

5

1000 steps/day

Yes

13%

13%

  1. Abbreviations: SD standard deviation; IQR interquartile range
  2. a7 studies not included (Huffman, 2014; Dwyer, 2011; Herzig, 2014; Siddiqui, 2019; Tudor-Locke, 2004; Van Dyck, 2013; Yates, 2015) due to analytic methods that could not be harmonized
  3. bExposure of daily steps standardized to 1000 steps/day at baseline and an assumed linear association
  4. cYamamoto, 2018 reported that the linear association between daily step counts and all-cause mortality was not statistically significant. All other studies in the table reported finding a statistically significant linear association between daily step counts and the outcome