New global guidelines on sedentary behaviour and health for adults: broadening the behavioural targets

Table 3 Summary of relationships and level of evidence for sedentary behaviour and each health outcome in adults

Health Outcomes	Evidence for association	Evidence for dose-response ^c	Evidence for variation in association by physical activity	Evidence for type or domain of sedentary behaviour
All-cause mortality	Moderate	Moderate	Moderate	Insufficient
CVD mortality	Moderate	Moderate	Moderate	Insufficient
Cancer mortality	Moderate	Moderate	Moderate	Insufficient
Incident type 2 diabetes	Moderate	Low	Insufficient	Insufficient
Incident CVD	Moderate	Moderate	Insufficient	Insufficient
Incident cancer ^a	Low-moderate ^b	Low	Insufficient	Insufficient
Adiposity	Low/insufficient	Low/insufficient	Insufficient	Insufficient

See the WHO report [16] for details on the framework to rate the certainty of the evidence and the full evidence profiles
^a Includes endometrial, colon, and lung cancers. Evidence graded very low to low certainty for other cancer types
^b Level of evidence rating based on evidence from PAGAC reviews [9]
^c It was concluded that there was insufficient evidence to set quantified (time-based) recommendations

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