Table 2 Quality/risk of bias assessment for the included GWAS and candidate gene studies. Studies sorted in descending order according to quality score (high to low)
From: Genetic variants related to physical activity or sedentary behaviour: a systematic review
1st Author (year) | Incl./ excl. | Pop. strat. | Sample/ power | DNA sampl. | Genotyping | Hardy-Weinb. | Phenotype definition | Strength assoc.a | Replicateda | Sum (0–12) | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Method descr. | Quality control | Blinded | Assesment descr. | Valid. instr. | Object. measure | |||||||||
GWAS | ||||||||||||||
Doherty (2018) [27] | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | N/A | 0 | 9 |
Klimentidis (2018) [30] | 0.5 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | N/A | 1 | 8.5 |
Hara (2018) [29] | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | (1)b | 1 | 8 |
De Moor (2009) [28] | 0.5 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | (0)b | 1 | 7.5 |
Kim (2014) [75] | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | N/A | 1 (bootstrapping) | 7 |
Lin (2018) [31] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | (1)b | 1 | 7 |
Candidate gene studies | ||||||||||||||
Bruneau (2017) [32] | 1 | 0.5 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | N/A | 9.5 |
Bruneau (2018) [33] | 1 | 0.5 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | N/A | 9.5 |
Liu (2010) [41] | 1 | 0.5 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | N/A | 9.5 |
Gielen (2014) [37] | 1 | 0.5 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | N/A | 8.5 |
Jozkow (2011) [91] | 1 | 0.5 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | N/A | 8.5 |
Jozkow (2013) [92] | 1 | 0.5 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | N/A | 8.5 |
Murakami (2014) [45] | 1 | 0.5 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | N/A | 8.5 |
West (2018) [102] | 1 | 0.5 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | N/A | 8.5 |
Camps (2019) [35] | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | N/A | 8 |
Maestu (2013) [43] | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | N/A | 8 |
Van der Mee (2018) [99] | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | N/A | 8 |
Cole (2010) [34] | 1 | 0.5 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | N/A | 7.5 |
Vimaleswaran (2010) [100] | 0.5 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | N/A | 7.5 |
Wong (2012) [52] | 1 | 0.5 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | N/A | 7.5 |
Espinosa- Salinas (2019) [79] | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | N/A | 7 |
Flack (2019) [36] | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | N/A | 7 |
Goleva-Fjellet (2020) [82] | 0.5 | 0.5 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | N/A | 7 |
Huppertz (2014) [88] | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | N/A | 7 |
Lee (2015) [40] | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | N/A | 7 |
Many (2017) [44] | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | N/A | 7 |
Reddon (2016) [47] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | N/A | 7 |
Van Deveire (2012) [49] | 0.5 | 0.5 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | N/A | 7 |
Adamska- Patruno (2019) [76] | 0.5 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | N/A | 6.5 |
Fonseca-Portilla (2019) [80] | 1 | 0.5 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | N/A | 6.5 |
Haber (2010) [85] | 0 | 0.5 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | N/A | 6.5 |
Hakanen (2009) [38] | 0.5 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | N/A | 6.5 |
Harbron (2018) [86] | 1 | 0.5 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | N/A | 6.5 |
Hubacek (2011) [87] | 1 | 0.5 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | N/A | 6.5 |
Jozkow (2009) [90] | 1 | 0.5 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | N/A | 6.5 |
Lorentzon (2001) [94] | 1 | 0.5 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | N/A | 6.5 |
Moleres (2009) [96] | 0.5 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | N/A | 6.5 |
Richert (2007) [48] | 1 | 0.5 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | N/A | 6.5 |
Walsh (2012) [101] | 1 | 0.5 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | N/A | 6.5 |
Jensen (2014) [89] | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | N/A | 6 |
Kirac (2016) [93] | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | N/A | 6 |
Klimentidis (2016) [39] | 0.5 | 0.5 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | N/A | 6 |
Loos (2005) [42] | 0.5 | 0.5 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | N/A | 6 |
Luglio (2016) [95] | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | N/A | 6 |
Berentzen (2008) [77] | 1 | 0.5 | 0 | 0a | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | N/A | 5,5 |
Fuentes (2002) [81] | 1 | 0.5 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | N/A | 5.5 |
Murakami (2017) [46] | 1 | 0.5 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0c | 1 | N/A | 5.5 |
Wilkinson (2013) [50] | 0.5 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | N/A | 5.5 |
Simonen (2003) [98] | 0.5 | 0.5 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | (1)d | 5 |
Winnicki (2004) [51] | 0.5 | 0.5 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | N/A | 5 |
Boer (1997) [78] | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | N/A | 4 |
Grady (2013) [84] | 0.5 | 0.5 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | N/A | 4 |
Salmen (2003) [97] | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | N/A | 4 |
Good (2015) [83] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | N/A | 1 |