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Table 13 Adjusteda mean incremental costs, incremental QALYs, and incremental cost-effectiveness ratio over 12 months between intervention group vs usual care group from NHS perspective

From: A novel approach to increasing community capacity for weight management a volunteer-delivered programme (ActWELL) initiated within breast screening clinics: a randomised controlled trial

Analysis Incremental mean costs, £ (95% CI)b,c,d Incremental mean QALYs (95% CI)b,c,d ICER (£/QALY)
Complete casese 541.74 (429.71 to 656.68) 0.006 (−0.015 to 0.029) 83,440
SA: Decrease time spent to 50% by staff on intervention-related activities (complete case) 500.72 (388.85 to 615.17) 0.006 (−0.015 to 0.029) 77,123
SA: Increase time spent to 70% by staff on intervention-related activities (complete case) 582.68 (470.66 to 698.07) 0.006 (−0.015 to 0.029) 89,746
SA: Lower intervention cost (complete cases)f 358.74 (247.92 to 471.38) 0.006 (−0.015 to 0.029) 55,255
SA: Imputed dataset 548.94 (447.10 to 649.20) 0.006 (−0.012 to 0.022) 99,804
  1. Abbreviations: QALYs quality-adjusted life-years, ICER incremental cost-effectiveness ratio, SA sensitivity analysis
  2. aAdjusted for baseline differences (age, Scottish Index of Multiple Deprivation, employment status, smoking status, body mass index, alcohol intake, eating habits, physical activity time, baseline EQ-5D health utility score and baseline cost)
  3. bBootstrapped non-parametric 95% confidence interval (2.5th/97.5th percentile)
  4. cGeneralised linear model with Poisson distribution and power 0.5 link function to estimate incremental costs and generalised linear model with Gaussian distribution and identity link function to estimate incremental QALYs (complete cases)
  5. dDiscounted at 3.5% per year
  6. eIncluded intervention cost of £505 per participant. This consists of staff cost, lifestyle coaches training cost and ActWELL delivery cost. Based on the activities performed from Jan 2017 to Dec 2019, 60% staff time was spent on coach recruitment, training, support and management
  7. fIncluded intervention cost of £326 per participant. This considers costs that would accrue when ActWELL programme is rolled out in ‘real life’ and in steady state. Staff cost (1-year salary of all staffs), training cost and ActWELL delivery cost were included