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Table 1 Baseline clinical characteristics

From: Association between cardiac autonomic function and physical activity in patients at high risk of sudden cardiac death: a cohort study

Parameters Total (n = 342) Tertile 1 (n = 114) Tertile 2 (n = 114) Tertile 3 (n = 114) P value
Home monitoring data
 Baseline PA, % 10.80 ± 5.35 5.18 ± 2.01 10.30 ± 1.48 16.93 ± 3.19
 Baseline HRV, ms 71.14 ± 27.63 62.40 ± 25.43 72.23 ± 26.87 78.80 ± 28.85
Demographics
 Gender, male 78.4% (268) 76.3% (87) 74.6% (85) 84.2% (96) P = 0.169
 Age at implantation, years 62.37 ± 13.48 66.32 ± 13.66 63.26 ± 13.07 57.52 ± 12.26 P < 0.001
 BMI, Kg/m2 23.56 ± 2.87 23.62 ± 2.85 23.53 ± 3.26 23.72 ± 2.45 P = 0.890
CRT-D implantation 53.8% (184) 51.8% (59) 57.9% (66) 51.8% (59) P = 0.562
 NYHA, Class III-IV 61.4% (210) 67.5% (77) 61.4% (70) 55.3% (63) P = 0.163
Echocardiography
 LVEF, % 39.13 ± 14.43 38.64 ± 14.61 39.48 ± 14.20 39.29 ± 14.60 P = 0.900
 LVEDD, mm 62.38 ± 13.20 60.17 ± 11.36 62.76 ± 13.69 64.23 ± 14.18 P = 0.066
Comorbidities
 Hypertension 35.1% (120) 39.5% (45) 43.0% (49) 22.8% (26) P = 0.003
 DM 14.6% (50) 17.5% (20) 14.0% (16) 12.3% (14) P = 0.519
 Stroke 2.6% (9) 7.0% (8) 0.9% (1) 0.0% (0) P = 0.001
 DCM 29.8% (102) 28.9% (33) 29.8% (34) 30.7% (35) P = 0.959
 HCM 3.8% (13) 0.9% (1) 5.3% (6) 5.3% (6) P = 0.081
 ICM 39.8% (136) 47.7% (54) 42.1% (48) 29.8% (34) P = 0.021
 Valve disease 2.3% (8) 3.5% (4) 1.8% (2) 1.8% (2) P = 0.671
 Prior MI 14.0% (48) 20.2% (23) 12.3% (14) 9.6% (11) P = 0.059
 PCI 11.7% (40) 21.1% (24) 9.6% (11) 4.4% (5) P < 0.001
 CABG 1.8% (6) 3.5% (4) 0.0% (0) 1.8% (2) P = 0.060
 Prior paroxysmal AF 7.6% (26) 9.6% (11) 7.0% (8) 6.1% (7) P = 0.582
 LQTS 1.5% (5) 0.9% (1) 1.8% (2) 1.8% (2) P = 0.801
 Pre-implant syncope 15.8% (54) 19.3% (22) 9.6% (11) 18.4% (21) P = 0.087
Medication
 ACEIs/ARBs 41.5% (142) 43.0% (49) 43.9% (50) 37.7% (43) P = 0.596
 Diuretics 33.0% (113) 39.5% (45) 31.6% (36) 28.1% (32) P = 0.172
 Aldosterone antagonists 45.0% (154) 51.8% (59) 41.2% (47) 42.1% (48) P = 0.208
 CCBs 10.2% (35) 2.0% (7) 5.6% (19) 2.6% (9) P = 0.019
 Statins 22.8% (78) 24.6% (28) 28.1% (32) 15.8% (18) P = 0.075
 Beta-blockers 57.6% (197) 57.0% (65) 57.9% (66) 57.9% (66) P = 0.988
 Amiodarone 28.1% (96) 27.2% (31) 23.7% (27) 33.3% (38) P = 0.260
 Antiplatelets 21.6% (74) 27.2% (31) 22.8% (26) 14.9% (17) P = 0.074
  1. ACEIs angiotensin-converting enzyme inhibitors, AF atrial fibrillation, ARBs angiotensin receptor blockers, BMI body mass index, CABG coronary artery bypass grafting, CCB calcium channel blockers, CRT-D cardiac resynchronization therapy with defibrillation, DCM dilated cardiomyopathy, DM diabetes mellitus, HCM hypertrophic cardiomyopathy, HRV heart rate variability, ICM ischemic cardiomyopathy, LQTS long QT syndrome, LVEF left ventricular ejection fraction, LVEDD left ventricular end-diastolic dimension, MI myocardial infarction, PA physical activity, PCI percutaneous coronary intervention