From: Healthy lifestyle, metabolomics and incident type 2 diabetes in a population-based cohort from Spain
Adjustment models | Difference in type 2 diabetes rates per 10,000 person-years (95% CI) | Percent explained, % (95% CI)c |
---|---|---|
Age, sex, education, prevalent hypertension, total plasma cholesterol, use of lipid lowering medication (Reference Model) | ā8.23 (āā16.3, āā0.13) | Reference |
Reference model + lipoprotein subclasses | ā4.45 (āā12.65, 3.75) | 45.9 (3.6, 238.7) |
Reference model + amino acids | ā4.49 (āā13.06, 4.08) | 45.4 (7.2, 274.0) |
Reference model + fatty acids | ā6.38 (ā15.00, 2.24) | 22.5 (ā11.2, 164.1) |
Reference model + fluid balance | ā6.12 (āā14.58, 2.34) | 25.6 (4.4, 223.7) |
Reference model + energy | ā5.20 (ā13.93, 3.54) | 36.8 (0.3, 285.2) |
Reference model + products of bacterial co-metabolism | ā5.10 (āā13.82, 3.62) | 38.0 (2.8, 266.2) |
Reference model + O-phosphoethanolamine | ā6.24 (āā14.79, 2.31) | 24.2 (2.9, 211.3) |
Reference model + phenylpropionate, and medium HDL and small LDL particle concentrations b | ā3.91 (āā12.25, 4.44) | 52.5 (15.9, 384.3) |