Mediterranean diet and depression: a population-based cohort study

Table 3 The association between adherence to the Mediterranean dietary pattern and risk of depression based on different definitions

Adherence to MDP	Broad definition ^a			Narrow definition ^b			Severe depression ^c
Adherence to MDP	Case/participants, N	Minimally adjusted HR ^d	Fully adjusted HR ^e	Case, N	Minimally adjusted HR	Fully adjusted HR	Case, N	Minimally adjusted HR	Fully adjusted HR
Low(0-3)	2644/14,453	ref.	ref.	465	ref.	ref.	97	ref.	ref.
Medium(4-5)	3134/18,540	0.91 (0.86-0.96)	0.94 (0.89-0.99)	499	0.84 (0.74-0.95)	0.88 (0.78-1.01)	97	0.79 (0.60-1.05)	0.79 (0.60-1.06)
High(6-9)	1568/9522	0.89 (0.83-0.95)	0.94 (0.88-1.00)	227	0.76 (0.64-0.89)	0.83 (0.70-0.97)	31	0.51 (0.34-0.76)	0.51 (0.33-0.76)
Per unit increase	7346/42,515	0.97 (0.96-0.98)	0.99 (0.97-1.00)	1191	0.93 (0.89-0.96)	0.95 (0.91-0.98)	225	0.89 (0.82-0.97)	0.89 (0.82-0.97)

^a Broad definition: ≥1 dispense of SSRIs or clinical diagnosis of depression
^b Narrow definition: Both dispense of SSRIs and clinical diagnosis of depression
^c Severe depression: Based on International Classification of Disease codes: ICD-10 F32.2, F32.3, F33.2 and F33.3
^d HRs (hazard ratios) and 95% CI (confidence intervals) were derived from Cox models using attained age as the time scale, adjusted for year of birth (1942-46, 1947-51, 1952-56 and 1957-62)
^e HRs (hazard ratios) and 95% CI (confidence intervals) were derived from Cox models using attained age as the time scale, adjusted for year of birth, body mass index, smoking, physical activity, total energy intake, years of education years, and history of diabetes and hypertension
MDP Mediterranean dietary pattern

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