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Table 2 Associations between physical activity trajectories and incidence of premature cardiovascular disease (CVD) events in the CARDIA study

From: Physical activity from young adulthood to middle age and premature cardiovascular disease events: a 30-year population-based cohort study

 

Model 1 (adjusted for age)a

Model 2 (fully adjusted)b

Model 3 (fully adjusted with mediators)c

 

OR

95% CI

p

OR

95% CI

p

OR

95% CI

p

% Mediation

95% CI

p

Any coronary heart disease (CHD) - fatal or nonfatal (myocardial infarction, non-myocardial infarction acute coronary syndrome)

 Lower physical activity score (per 100 Exercise Units) at age 18

1.04

0.95, 1.14

0.400

1.14

1.02, 1.28

0.025

1.08

0.96, 1.21

0.200

43%

4, 82%

0.029

 Annual reduction in total physical activity score (per 1 Exercise Unit)

1.05

1.02, 1.09

0.004

1.03

0.99, 1.07

0.160

1.01

0.97, 1.05

0.760

78%

−35, 191%

0.17

Any heart failure - fatal or nonfatal (congestive heart failure)

 Lower physical activity score (per 100 Exercise Units) at age 18

1.26

1.10, 1.45

< 0.001

1.21

1.05, 1.38

0.008

1.13

1.00, 1.28

0.058

35%

11, 58%

0.004

 Annual reduction in total physical activity score (per 1 Exercise Unit)

1.17

1.10, 1.24

< 0.001

1.07

1.02, 1.13

0.011

1.04

0.99, 1.10

0.120

38%

3, 72%

0.032

Any stroke - fatal or nonfatal (stroke, transient ischemic attack)

 Lower physical activity score (per 100 Exercise Units) at age 18

1.32

1.16, 1.50

< 0.001

1.20

1.04, 1.39

0.013

1.14

0.99, 1.31

0.07

30%

6, 53%

0.013

Annual reduction in total physical activity score (per 1 Exercise Unit)

1.14

1.07, 1.21

< 0.001

1.06

1.00, 1.13

0.040

1.04

0.98, 1.10

0.180

35%

−2, 73%

0.06

Any CVD - fatal or nonfatal (myocardial infarction, coronary revascularization, non-NI acute coronary syndrome, congestive heart failure, stroke, transient ischemic attack, carotid artery disease, peripheral artery disease, abdominal aortic aneurysm)

 Lower physical activity score (per 100 Exercise Units) at age 18

1.12

1.05, 1.20

< 0.001

1.15

1.06, 1.24

< 0.001

1.08

1.00, 1.17

0.037

41%

17, 66%

< 0.001

 Annual reduction in total physical activity score (per 1 Exercise Unit)

1.08

1.05, 1.11

< 0.001

1.04

1.01, 1.07

0.011

1.02

0.99, 1.04

0.300

59%

10, 108%

0.019

  1. Note: Boldface indicates statistical significance (p < 0.05)
  2. aModel 1 includes: physical activity level at age 18, annual reduction in physical activity, age. Separate models are presented for each outcome (CHD, heart failure, stroke, CVD)
  3. bModel 2 includes: physical activity level at age 18, annual reduction in physical activity, age, race, sex, education, income, family history of CVD, smoking status, and alcohol. Separate models are presented for each outcome (CHD, heart failure, stroke, CVD)
  4. cModel 3 includes: physical activity level at age 18, annual reduction in physical activity, age, race, sex, education, income, family history of CVD, smoking status, alcohol, body mass index, hypertension, diabetes, and dyslipidemia. Separate models are presented for each outcome (CHD, heart failure, stroke, CVD)
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International Journal of Behavioral Nutrition and Physical Activity

ISSN: 1479-5868

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