Total population (n = 212) | Missing values (n (%)) | SIT LESS group (n = 108) | Control group (n = 104) | |
---|---|---|---|---|
Patient characteristics | ||||
Age (years) | 63 (± 10) | 0 (0%) | 63 (± 10) | 64 (± 10) |
Sex (female) | 48 (23%) | 0 (0%) | 25 (23%) | 23 (22%) |
Body mass index (kg/m2) | 27.1 [24.6–30.2] | 0 (0%) | 27.1 [24.6–30.1] | 27.2 [24.6–30.8] |
Ethnicity | 0 (0%) | |||
Dutch (n (%)) | 201 (95%) | 104 (96%) | 97 (93%) | |
Asian (n (%)) | 4 (2%) | 0 (0%) | 4 (4%) | |
European other (n (%)) | 3 (2%) | 1 (1%) | 2 (2%) | |
South-American (n (%)) | 3 (1%) | 2 (2%) | 1 (1%) | |
African (n (%)) | 1 (0%) | 1 (1%) | 0 (0%) | |
Education level | 20 (9%) | |||
Low (n (%)) | 46 (24%) | 19 (20%) | 27 (28%) | |
Middle (n (%)) | 77 (40%) | 38 (40%) | 39 (30%) | |
High (n (%)) | 69 (36%) | 38 (40%) | 31 (32%) | |
Living together/married | 152 (79%) | 20 (9%) | 77 (81%) | 75 (77%) |
Working status | ||||
Employed | 98 (51%) | 20 (9%) | 53 (49%) | 45 (46%) |
Mainly sedentary at work (n (%)) | 35 (36%) | 20 (38%) | 15 (33%) | |
Some light physical activities at work (n (%)) | 20 (20%) | 13 (24%) | 7 (16%) | |
Light to moderate physical activities at work (n (%)) | 10 (10%) | 4 (8%) | 6 (13%) | |
Moderate to vigorous physical activities at work (n (%)) | 33 (34%) | 16 (30%) | 17 (38%) | |
Unemployed | 94 (44%) | 20 (9%) | 42 (44%) | 52 (54%) |
Retirement (n (%)) | 80 (85%) | 37 (88%) | 43 (83%) | |
Health problems (n (%)) | 13 (14%) | 4 (10%) | 9 (17%) | |
Household tasks (n (%)) | 1 (1%) | 1 (2%) | 0 (0%) | |
Monthly household income (€) | 37 (17%) | |||
< 2000 (n (%)) | 35 (20%) | 19 (22%) | 16 (17%) | |
2000 – 3999 (n (%)) | 95 (54%) | 44 (52%) | 51 (56%) | |
4000 – 5999 (n (%)) | 35 (20%) | 18 (21%) | 17 (19%) | |
≥ 6000 (n (%)) | 10 (6%) | 4 (5%) | 6 (8%) | |
Living environment | 19 (9%) | |||
Transition (n (%)) | 89 (46%) | 43 (45%) | 46 (47%) | |
Urban (n (%)) | 54 (28%) | 23 (24%) | 31 (32%) | |
Rural (n (%)) | 50 (26%) | 29 (31%) | 21 (21%) | |
Regular step count tracking by smartwatch or smartphone (n (%)) | 71 (34%) | 0 (0%) | 33 (31%) | 38 (37%) |
Lifestyle factors | ||||
Alcohol use (n (%)) | 168 (79%) | 0 (0%) | 87 (81%) | 81 (78%) |
Current drinker (n (%)) | 146 (87%) | 75 (86%) | 71 (88%) | |
Units/week (n) | 5 [2-10] | 5 [3-9] | 5 [2-14] | |
Smoking (n (%)) | 150 (71%) | 0 (0%) | 73 (68%) | 77 (74%) |
Current smoker (n (%)) | 41 (27%) | 19 (26%) | 22 (28%) | |
Packyears (n) | 23 [10-36] | 23 [10-37] | 22 [10-36] | |
Medical history | ||||
Comorbidities | 0 (0%) | |||
Hypertension (n (%)) | 85 (40%) | 41 (38%) | 44 (42%) | |
Dyslipidaemia (n (%)) | 66 (31%) | 34 (32%) | 32 (31%) | |
Diabetes mellitus (n (%)) | 36 (17%) | 17 (16%) | 19 (18%) | |
Prior myocardial infarction (n (%)) | 33 (16%) | 18 (17%) | 15 (14%) | |
Prior PCI (n (%)) | 26 (12%) | 17 (16%) | 9 (9%) | |
Prior CABG (n (%)) | 9 (4%) | 7 (6%) | 2 (2%) | |
Atrial fibrillation (n (%)) | 18 (9%) | 7 (7%) | 11 (11%) | |
Heart failure with reduced ejection fraction (n (%)) | 17 (8%) | 10 (9%) | 7 (7%) | |
Peripheral artery disease (n (%)) | 17 (8%) | 8 (7%) | 9 (9%) | |
Heart valve disease (n (%)) | 15 (7%) | 12 (11%) | 3 (3%) | |
Depression (n (%)) | 12 (6%) | 7 (7%) | 5 (5%) | |
Cancer (diagnosed in the past 5 years) (n (%)) | 12 (6%) | 8 (7%) | 4 (4%) | |
Rheumatoid arthritis (n (%)) | 8 (4%) | 4 (4%) | 4 (4%) | |
COPD (n (%)) | 8 (4%) | 3 (3%) | 5 (5%) | |
CVA (n (%)) | 8 (4%) | 3 (3%) | 5 (5%) | |
TIA (n (%)) | 7 (3%) | 3 (3%) | 4 (4%) | |
Chronic renal failure (eGFR < 30 ml/min/1.73m2 or dialysis) (n (%)) | 7 (3%) | 6 (6%) | 1 (1%) | |
Hospitalisation | ||||
Out of hospital cardiac arrest (n (%)) | 7 (3%) | 0 (0%) | 4 (4%) | 3 (3%) |
Index diagnosis | 0 (0%) | |||
Non-ST-elevation myocardial infarction (n (%)) | 102 (48%) | 57 (53%) | 45 (43%) | |
ST-elevation myocardial infarction (n (%)) | 64 (30%) | 30 (28%) | 34 (33%) | |
Stable angina pectoris (n (%)) | 30 (14%) | 14 (13%) | 16 (15%) | |
Unstable angina pectoris (n (%)) | 16 (8%) | 7 (7%) | 9 (9%) | |
Coronary angiography findings | 0 (0%) | |||
1-vessel disease (n (%)) | 113 (53%) | 60 (56%) | 53 (51%) | |
2-vessel disease (n (%)) | 49 (23%) | 22 (20%) | 27 (26%) | |
3-vessel disease (n (%)) | 41 (19%) | 20 (19%) | 21 (20%) | |
No significant stenosis (n (%)) | 9 (4%) | 6 (6%) | 3 (3%) | |
Treatment | 0 (0%) | |||
PCI (n (%)) | 126 (59%) | 62 (57%) | 64 (62%) | |
CABG (n (%)) | 56 (26%) | 28 (26%) | 28 (27%) | |
Conservative (optimal medical treatment only) (n (%)) | 30 (14%) | 18 (17%) | 12 (12%) | |
Laboratory values | ||||
Peak hs-cTnT (ng/L) (Bernhoven cohort) | 1977 [380–19151] | 22 (21%) | 2083 [437–24275] | 1496 [352–16206] |
Peak hs-cTnI (ng/L) (Rijnstate cohort) | 5155 [500–23984] | 10 (10%) | 3668 [291–25000] | 5554 [655–22276] |
Peak CK (U/L) | 199 [104–508] | 34 (16%) | 236 [113–526] | 180 [99–475] |
Total cholesterol (mmol/L) | 5.0 (± 1.4) | 36 (17%) | 4.9 (± 1.2) | 5.1 (± 1.5) |
LDL-cholesterol (mmol/L) | 3.0 (± 1.2) | 37 (18%) | 2.9 (± 1.1) | 3.1 (± 1.3) |
HDL-cholesterol (mmol/L) | 1.1 (± 0.3) | 36 (17%) | 1.2 (± 0.4) | 1.1 (± 0.3) |
Triglycerides (mmol/L) | 1.4 [1.0–2.2] | 36 (17%) | 1.4 [1.0–2.0] | 1.5 [1.0–2.5] |
In-hospital complications (n (%)) | 17 (8%) | 0 (0%) | 8 (8%) | 9 (9%) |
Complicated PCI (n (%)) | 6 (3%) | 3 (3%) | 3 (3%) | |
Complicated CABG (n (%)) | 5 (2%) | 2 (2%) | 3 (3%) | |
Target vessel revascularisation (n (%)) | 2 (1%) | 1 (1%) | 1 (1%) | |
Ischemic CVA (n (%)) | 2 (1%) | 1 (1%) | 1 (1%) | |
Major bleeding (n (%)) | 1 (0.5%) | 0 (0%) | 1 (1%) | |
In hospital cardiac arrest (n (%)) | 1 (0.5%) | 1 (1%) | 0 (0%) | |
Duration of hospitalisation (days) | 5 [3-9] | 0 (0%) | 5 [3-9] | 5 [3-10] |