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Table 1 Patient and disease-related characteristics of the study cohort

From: Effectiveness of an intervention to reduce sedentary behaviour as a personalised secondary prevention strategy for patients with coronary artery disease: main outcomes of the SIT LESS randomised clinical trial

 

Total population (n = 212)

Missing values (n (%))

SIT LESS group (n = 108)

Control group (n = 104)

Patient characteristics

Age (years)

63 (± 10)

0 (0%)

63 (± 10)

64 (± 10)

Sex (female)

48 (23%)

0 (0%)

25 (23%)

23 (22%)

Body mass index (kg/m2)

27.1 [24.6–30.2]

0 (0%)

27.1 [24.6–30.1]

27.2 [24.6–30.8]

Ethnicity

 

0 (0%)

  

 Dutch (n (%))

201 (95%)

 

104 (96%)

97 (93%)

 Asian (n (%))

4 (2%)

 

0 (0%)

4 (4%)

 European other (n (%))

3 (2%)

 

1 (1%)

2 (2%)

 South-American (n (%))

3 (1%)

 

2 (2%)

1 (1%)

 African (n (%))

1 (0%)

 

1 (1%)

0 (0%)

Education level

 

20 (9%)

  

 Low (n (%))

46 (24%)

 

19 (20%)

27 (28%)

 Middle (n (%))

77 (40%)

 

38 (40%)

39 (30%)

 High (n (%))

69 (36%)

 

38 (40%)

31 (32%)

Living together/married

152 (79%)

20 (9%)

77 (81%)

75 (77%)

Working status

Employed

98 (51%)

20 (9%)

53 (49%)

45 (46%)

  Mainly sedentary at work (n (%))

35 (36%)

 

20 (38%)

15 (33%)

  Some light physical activities at work (n (%))

20 (20%)

 

13 (24%)

7 (16%)

  Light to moderate physical activities at work (n (%))

10 (10%)

 

4 (8%)

6 (13%)

  Moderate to vigorous physical activities at work (n (%))

33 (34%)

 

16 (30%)

17 (38%)

Unemployed

94 (44%)

20 (9%)

42 (44%)

52 (54%)

  Retirement (n (%))

80 (85%)

 

37 (88%)

43 (83%)

  Health problems (n (%))

13 (14%)

 

4 (10%)

9 (17%)

  Household tasks (n (%))

1 (1%)

 

1 (2%)

0 (0%)

Monthly household income (€)

 

37 (17%)

  

  < 2000 (n (%))

35 (20%)

 

19 (22%)

16 (17%)

 2000 – 3999 (n (%))

95 (54%)

 

44 (52%)

51 (56%)

 4000 – 5999 (n (%))

35 (20%)

 

18 (21%)

17 (19%)

  ≥ 6000 (n (%))

10 (6%)

 

4 (5%)

6 (8%)

Living environment

 

19 (9%)

  

 Transition (n (%))

89 (46%)

 

43 (45%)

46 (47%)

 Urban (n (%))

54 (28%)

 

23 (24%)

31 (32%)

 Rural (n (%))

50 (26%)

 

29 (31%)

21 (21%)

Regular step count tracking by smartwatch or smartphone (n (%))

71 (34%)

0 (0%)

33 (31%)

38 (37%)

Lifestyle factors

Alcohol use (n (%))

168 (79%)

0 (0%)

87 (81%)

81 (78%)

 Current drinker (n (%))

146 (87%)

 

75 (86%)

71 (88%)

 Units/week (n)

5 [2-10]

 

5 [3-9]

5 [2-14]

Smoking (n (%))

150 (71%)

0 (0%)

73 (68%)

77 (74%)

 Current smoker (n (%))

41 (27%)

 

19 (26%)

22 (28%)

 Packyears (n)

23 [10-36]

 

23 [10-37]

22 [10-36]

Medical history

Comorbidities

 

0 (0%)

  

 Hypertension (n (%))

85 (40%)

 

41 (38%)

44 (42%)

 Dyslipidaemia (n (%))

66 (31%)

 

34 (32%)

32 (31%)

 Diabetes mellitus (n (%))

36 (17%)

 

17 (16%)

19 (18%)

 Prior myocardial infarction (n (%))

33 (16%)

 

18 (17%)

15 (14%)

 Prior PCI (n (%))

26 (12%)

 

17 (16%)

9 (9%)

 Prior CABG (n (%))

9 (4%)

 

7 (6%)

2 (2%)

 Atrial fibrillation (n (%))

18 (9%)

 

7 (7%)

11 (11%)

 Heart failure with reduced ejection fraction (n (%))

17 (8%)

 

10 (9%)

7 (7%)

 Peripheral artery disease (n (%))

17 (8%)

 

8 (7%)

9 (9%)

 Heart valve disease (n (%))

15 (7%)

 

12 (11%)

3 (3%)

 Depression (n (%))

12 (6%)

 

7 (7%)

5 (5%)

 Cancer (diagnosed in the past 5 years) (n (%))

12 (6%)

 

8 (7%)

4 (4%)

 Rheumatoid arthritis (n (%))

8 (4%)

 

4 (4%)

4 (4%)

 COPD (n (%))

8 (4%)

 

3 (3%)

5 (5%)

 CVA (n (%))

8 (4%)

 

3 (3%)

5 (5%)

 TIA (n (%))

7 (3%)

 

3 (3%)

4 (4%)

 Chronic renal failure (eGFR < 30 ml/min/1.73m2 or dialysis) (n (%))

7 (3%)

 

6 (6%)

1 (1%)

Hospitalisation

Out of hospital cardiac arrest (n (%))

7 (3%)

0 (0%)

4 (4%)

3 (3%)

Index diagnosis

 

0 (0%)

  

 Non-ST-elevation myocardial infarction (n (%))

102 (48%)

 

57 (53%)

45 (43%)

 ST-elevation myocardial infarction (n (%))

64 (30%)

 

30 (28%)

34 (33%)

 Stable angina pectoris (n (%))

30 (14%)

 

14 (13%)

16 (15%)

 Unstable angina pectoris (n (%))

16 (8%)

 

7 (7%)

9 (9%)

Coronary angiography findings

 

0 (0%)

  

 1-vessel disease (n (%))

113 (53%)

 

60 (56%)

53 (51%)

 2-vessel disease (n (%))

49 (23%)

 

22 (20%)

27 (26%)

 3-vessel disease (n (%))

41 (19%)

 

20 (19%)

21 (20%)

 No significant stenosis (n (%))

9 (4%)

 

6 (6%)

3 (3%)

Treatment

 

0 (0%)

  

 PCI (n (%))

126 (59%)

 

62 (57%)

64 (62%)

 CABG (n (%))

56 (26%)

 

28 (26%)

28 (27%)

 Conservative (optimal medical treatment only) (n (%))

30 (14%)

 

18 (17%)

12 (12%)

Laboratory values

 Peak hs-cTnT (ng/L) (Bernhoven cohort)

1977 [380–19151]

22 (21%)

2083 [437–24275]

1496 [352–16206]

 Peak hs-cTnI (ng/L) (Rijnstate cohort)

5155 [500–23984]

10 (10%)

3668 [291–25000]

5554 [655–22276]

 Peak CK (U/L)

199 [104–508]

34 (16%)

236 [113–526]

180 [99–475]

 Total cholesterol (mmol/L)

5.0 (± 1.4)

36 (17%)

4.9 (± 1.2)

5.1 (± 1.5)

 LDL-cholesterol (mmol/L)

3.0 (± 1.2)

37 (18%)

2.9 (± 1.1)

3.1 (± 1.3)

 HDL-cholesterol (mmol/L)

1.1 (± 0.3)

36 (17%)

1.2 (± 0.4)

1.1 (± 0.3)

 Triglycerides (mmol/L)

1.4 [1.0–2.2]

36 (17%)

1.4 [1.0–2.0]

1.5 [1.0–2.5]

In-hospital complications (n (%))

17 (8%)

0 (0%)

8 (8%)

9 (9%)

 Complicated PCI (n (%))

6 (3%)

 

3 (3%)

3 (3%)

 Complicated CABG (n (%))

5 (2%)

 

2 (2%)

3 (3%)

 Target vessel revascularisation (n (%))

2 (1%)

 

1 (1%)

1 (1%)

 Ischemic CVA (n (%))

2 (1%)

 

1 (1%)

1 (1%)

 Major bleeding (n (%))

1 (0.5%)

 

0 (0%)

1 (1%)

 In hospital cardiac arrest (n (%))

1 (0.5%)

 

1 (1%)

0 (0%)

Duration of hospitalisation (days)

5 [3-9]

0 (0%)

5 [3-9]

5 [3-10]

  1. Data are presented as n (%) for categorical variables and as mean (± standard deviation) or median [interquartile range] for continuous variables
  2. CABG Coronary artery bypass grafting, COPD Chronic obstructive pulmonary disease, CK Creatine kinase, CVA Cerebrovascular accident, HDL High-density lipoprotein, hs-cTnI High-sensitive cardiac Troponin-I, hs-cTnT High-sensitive cardiac Troponin-T, LAD Left anterior descending artery, LDL Low-density lipoprotein, LM Left main, PCI Percutaneous Coronary Intervention, RCA Right coronary artery, RCx Ramus circumflex artery, TIA Transient ischemic attack