The independent and joint association of accelerometer-measured physical activity and sedentary time with dementia: a cohort study in the UK Biobank

Zhong, Qi; Zhou, Rui; Huang, Yi-Ning; Chen, Hao-Wen; Liu, Hua-Min; Huang, Zhiwei; Yuan, Zelin; Wu, Keyi; Cao, Bi-Fei; Liu, Kuan; Fan, Wei-Dong; Liang, Yong-Qi; Wu, Xian-Bo

doi:10.1186/s12966-023-01464-8

Table 2 Association of TPA and sedentary time with incident dementia and its subtypes

From: The independent and joint association of accelerometer-measured physical activity and sedentary time with dementia: a cohort study in the UK Biobank

	Events/N	Incidence rate (per 1000 person-years)	Crude model		Model 1		Model 2
	Events/N	Incidence rate (per 1000 person-years)	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value
All-cause dementia
TPA, milli-g
Low	369/45180	1.20	Ref		Ref		Ref
High	132/45140	0.43	0.35 (0.29, 0.43)	< 0.001	0.57 (0.47, 0.70)	< 0.001	0.58 (0.47, 0.71)	< 0.001
Continuous (per 10 mg)	501/90,320	0.81	0.44 (0.39, 0.50)	< 0.001	0.62 (0.55, 0.70)	< 0.001	0.63 (0.55, 0.71)	< 0.001
Sedentary time, h/ day
Low	205/45,439	0.66	Ref		Ref		Ref
High	296/44,881	0.97	1.48 (1.24, 1.77)	< 0.001	1.24 (1.03, 1.48)	0.020	1.22 (1.02, 1.47)	0.032
Continuous (per 0.5 h)	501/90,320	0.81	1.08 (1.05, 1.10)	< 0.001	1.04 (1.01, 1.07)	0.004	1.03 (1.01, 1.06)	0.014
Alzheimer’s disease
TPA, milli-g
Low	143/45180	0.47	Ref		Ref		Ref
High	56/45,180	0.18	0.39 (0.28, 0.53)	< 0.001	0.65 (0.47, 0.89)	< 0.007	0.63 (0.45, 0.87)	0.004
Continuous (per 10 mg)	199/90,320	0.32	0.53 (0.44, 0.64)	< 0.001	0.76 (0.62, 0.92)	0.004	0.74 (0.60, 0.90)	0.003
Sedentary time, h/ day
Low	86/45439	0.28	Ref		Ref		Ref
High	113/44881	0.37	1.34 (1.01, 1.78)	0.039	1.14 (0.86, 1.51)	0.366	1.16 (0.87, 1.55)	0.305
Continuous (per 0.5 h)	199/90,320	0.32	1.05 (1.01, 1.10)	0.014	1.02 (0.98, 1.06)	0.342	1.02 (0.98, 1.07)	0.319
Vascular dementia
TPA, milli-g
Low	63/45180	0.21	Ref		Ref		Ref
High	31/45140	0.09	0.48 (0.31, 0.74)	0.001	0.84 (0.54, 1.29)	0.421	0.93 (0.59, 1.47)	0.759
Continuous (per 10 mg)	94/90,320	0.15	0.43 (0.33, 0.57)	< 0.001	0.63 (0.48, 0.85)	0.002	0.69 (0.51, 0.93)	0.013
Sedentary time, h/ day
Low	45/45439	0.14	Ref		Ref		Ref
High	49/44881	0.16	1.12 (0.74, 1.67)	0.597	0.89 (0.59, 1.34)	0.565	0.83 (0.55, 1.27)	0.392
Continuous (per 0.5 h)	94/90,320	0.15	1.03 (0.97, 1.09)	0.403	0.98 (0.93, 1.05)	0.606	0.97 (0.91, 1.03)	0.288

Model 1 adjusted for age at baseline, sex, ethnicity, education and Townsend deprivation index
Model 2 additionally adjusted for smoking status, alcohol intake frequency, body mass index, baseline cardiovascular disease, hypertension, diabetes, cancer and depression
Abbreviations: TPA total volume of physical activity, milli-g

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