TPA, milli-g | Sedentary time, hours/ day | Events/N | Incidence rate (per 1000 person-years) | HR (95% CI) | P value | Additive interaction (RERI) | Multiplicative interaction | ||
---|---|---|---|---|---|---|---|---|---|
Estimates (95% CI) | P value | Estimates (95% CI) | P value | ||||||
All-cause dementia |  |  |  |  | 0.25 (− 0.26, 0.77) | 0.335 | 1.31 (0.79, 2.18) | 0.295 | |
 High | Low | 109/34371 | 0.46 | Ref |  |  |  |  |  |
 High | High | 23/10769 | 0.31 | 0.78 (0.50, 1.22) | 0.274 |  |  |  |  |
 Low | Low | 96/11068 | 1.28 | 1.62 (1.23, 2.15) | 0.001 |  |  |  |  |
 Low | High | 273/34112 | 1.18 | 1.65 (1.31, 2.09) |  < 0.001 |  |  |  |  |
Alzheimer’s disease |  |  |  |  | 0.26 (− 0.51, 1.03) | 0.502 | 1.42 (0.64, 3.17) | 0.391 | |
 High | Low | 47/34371 | 0.20 | Ref |  |  |  |  |  |
 High | High | 9/10769 | 0.12 | 0.74 (0.36, 1.52) | 0.413 |  |  |  |  |
 Low | Low | 39/11068 | 0.52 | 1.51 (0.98, 2.32) | 0.062 |  |  |  |  |
 Low | High | 104/34112 | 0.45 | 1.51 (1.06, 2.17) | 0.024 |  |  |  |  |
Vascular dementia |  |  |  |  | 0.33 (− 0.48, 1.13) | 0.427 | 1.74 (0.53, 5.69) | 0.359 | |
 High | Low | 27/34371 | 0.11 | Ref |  |  |  |  |  |
 High | High | 4/10,769 | 0.05 | 0.52 (0.18, 1.50) | 0.226 |  |  |  |  |
 Low | Low | 18/11068 | 0.24 | 1.07 (0.58, 1.97) | 0.828 |  |  |  |  |
 Low | High | 45/34112 | 0.19 | 0.92 (0.55, 1.52) | 0.738 |  |  |  |  |