Table 3 Independent^a and isotemporal substitution^b effects of sleeping, screen time, sitting, walking and non-walking moderate to vigorous physical activity on all-cause mortality risk. Participants who were considered healthy at baseline, defined as those who were never diagnosed with cardiovascular disease, diabetes, or cancer, (Imputed data^c, n = 143,680; 2690 deaths)

1. Isotemporal Substitution Model- Replace 1 hr of:

Sleeping (<=7 hrs)

Sleeping (>7 hrs)

Screen-time

Sitting

Standing

Walking

MVPA

Total activity

 A. Sleeping (<=7 hrs)

-

-

1.03 (0.97–1.09)

1.05 (0.98–1.11)

1.02 (0.96–1.08)

0.95 (0.81–1.11)

0.95 (0.86–1.04)

0.99 (0.94–1.05)

 B. Sleeping (>7 hrs)

-

0.98 (0.94–1.01)

0.98 (0.95–1.02)

0.94 (0.91–0.98)

0.88 (0.79–0.98)

0.89 (0.84–0.95)

1.04 (1.00–1.07)

 C. Screen-time

0.89 (0.83–0.95)

1.06 (1.02–1.1)

-

1.01 (0.99–1.04)

0.97 (0.95–0.99)

0.91 (0.84–0.99)

0.92 (0.87–0.96)

1.01 (1.00–1.03)

 D. Sitting

0.88 (0.82–0.94)

1.04 (1.00–1.08)

0.99 (0.96–1.01)

-

0.96 (0.94–0.98)

0.90 (0.83–0.98)

0.90 (0.86–0.95)

1.03 (1.01–1.04)

 E. Standing

0.91 (0.85–0.97)

1.08 (1.04–1.12)

1.03 (1.01–1.05)

1.04 (1.02–1.06)

-

0.93 (0.86–1.02)

0.94 (0.90–0.98)

0.99 (0.97–1.00)

 F. Walking

0.98 (0.88–1.08)

1.18 (1.11–1.26)

1.10 (1.01–1.20)

1.11 (1.02–1.21)

1.07 (0.98–1.16)

-

1.01 (0.91–1.11)

0.92 (0.85–1.00)

 G. MVPA

0.97 (0.90–1.05)

1.17 (1.11–1.23)

1.09 (1.04–1.14)

1.11 (1.06–1.16)

1.06 (1.02–1.11)

0.99 (0.90–1.10)

-

0.93 (0.89–0.97)

2. Partition model^a

0.99 (0.94–1.05)

1.06 (1.03–1.10)

1.02 (1.01–1.04)

1.03 (1.02–1.05)

0.98 (0.97–0.99)

0.89 (0.82–0.97)

0.91 (0.87–0.95)

-